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Results for "

Trypanosoma brucei

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (1) Aurora Kinase (1) Autophagy (2) Bacterial (2) COX (1) Cytochrome P450 (2) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fungal (1) Influenza Virus (1) Parasite (26) Phosphodiesterase (PDE) (2) Phospholipase (1) PKA (1) STAT (1)
By Research Areas:	Cancer (3) Infection (26) Inflammation/Immunology (4)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155655

JC-229

Parasite Infection

JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

JC-229	Parasite	Infection
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

HY-103056

DDD85646 IMP-366	DNA/RNA Synthesis Parasite	Infection
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .

HY-136200

Antitrypanosomal agent 2

Parasite Infection

Antitrypanosomal agent 2 is a potent and selective trypanosoma brucei inhibitor .

Antitrypanosomal agent 2	Parasite	Infection
Antitrypanosomal agent 2 is a potent and selective *trypanosoma* *brucei* inhibitor .

HY-147933

Antitrypanosomal agent 8	Parasite	Infection
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against **Trypanosoma brucei with an IC₅₀** value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC₅₀=80.95 μM) .

HY-147940

TbPTR1 inhibitor 1	Parasite	Infection
TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC₅₀<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC₅₀=0.66 μM) .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC₅₀ of 80 nM .

HY-N3418

Kolavenol	Parasite	Infection
Kolavenol is a diterpene, which can be isolated from Entada abyssinica. Kolavenol's diastereoisomer exhibits trypanocidal activity with an IC₅₀ value of 2.5 μg/mL (8.6 μM) against Trypanosoma brucei rhodesiense. While Trypanosoma brucei rhodesiense is the causing factor of the acute form of human African trypanosomiasis .

HY-119938

Tuberculosis inhibitor 1

Bacterial Infection

Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC₅₀ of 5 nM .
HY-N3247

Monomethyl kolavate

Parasite Others

Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

Tuberculosis inhibitor 1	Bacterial	Infection
Tuberculosis inhibitor 1 is a potent and non-cytotoxic **trypanosoma brucei growth inhibitor with an EC₅₀** of 5 nM .

Monomethyl kolavate	Parasite	Others
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

HY-157028

Antiparasitic agent-19	Others	Infection
Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .

HY-146049

Antitrypanosomal agent 4	Parasite	Infection
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC₅₀s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-142021

Z-Leu-Arg-AMC	Parasite	Infection
Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei .

HY-155207

Antileishmanial agent-23	Parasite	Infection
Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC₅₀ of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei .

HY-125731

Glycodeoxycholic Acid	Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-N7266

Obtusifoliol	Cytochrome P450 Parasite	Infection Cancer
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively .

HY-101015A

OBAA	Phospholipase Apoptosis	Inflammation/Immunology
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 nM. OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei with an IC₅₀ of 0.4 μM .

HY-144296

Purine phosphoribosyltransferase-IN-2	Parasite	Infection
Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with K_is of 30, 20 and 2 nM, respectively .

HY-147550

Antitrypanosomal agent 7	Parasite	Infection
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against **Trypanosoma brucei** (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .

HY-147549

Antitrypanosomal agent 6	Parasite	Infection
Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against **Trypanosoma brucei** (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .

HY-12054

Hesperadin Maximum Cited Publications 6 Publications Verification	Aurora Kinase Autophagy Influenza Virus Parasite	Cancer
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC₅₀ of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral .

HY-108938

SDZ285428	Cytochrome P450 Fungal Parasite	Infection
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .

HY-144294

Purine phosphoribosyltransferase-IN-1	Parasite	Infection
Purine phosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with K_i values of 50, 20, and 2 nM, respectively .

HY-126250

NPD-1335	Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology
NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death . NPD-1335 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111759

Jaspamycin 7-CN-7-C-Ino	PKA Parasite	Infection
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC₅₀ of 6.5 nM and K_d of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity .

HY-101015

(2E)-OBAA
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC₅₀ of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei, with an IC₅₀ of 0.4 μM .

HY-N0389

Columbin 1 Publications Verification	COX Parasite	Inflammation/Immunology
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-126417

Methylenetanshinquinone	Parasite	Infection
Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .

HY-147766

Antileishmanial agent-10

Parasite Infection

Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent .
HY-147765

Anti-Trypanosoma cruzi agent-3

Parasite Infection

Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .

Antileishmanial agent-10	Parasite	Infection
Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent .

Anti-Trypanosoma cruzi agent-3	Parasite	Infection
Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .

HY-14932

Pafuramidine 1 Publications Verification DB289	Parasite Antibiotic	Infection
Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria .

HY-14932A

Pafuramidine maleate DB289 maleate	Parasite Antibiotic	Infection
Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine (maleate) (DB289 (maleate)) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria .

HY-119480

Megazol	Bacterial	Infection
Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC₅₀ of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .

Glycodeoxycholic Acid	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite STAT Autophagy
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

Obtusifoliol	Infection Natural Products Human Gut Microbiota Metabolites Sorghum bicolor (Linn.) Moench Microorganisms Classification of Application Fields Gramineae Source classification Plants Endogenous metabolite Disease Research Fields	Cytochrome P450 Parasite
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively .

Columbin 1 Publications Verification	other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	COX Parasite
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

Kolavenol	Structural Classification Terpenoids Source classification Diterpenoids Solidago altissima Linnaeus Plants Compositae	Parasite
Kolavenol is a diterpene, which can be isolated from Entada abyssinica. Kolavenol's diastereoisomer exhibits trypanocidal activity with an IC₅₀ value of 2.5 μg/mL (8.6 μM) against Trypanosoma brucei rhodesiense. While Trypanosoma brucei rhodesiense is the causing factor of the acute form of human African trypanosomiasis .

Monomethyl kolavate	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Inula grandis Schrenk ex Fish..	Parasite
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

Methylenetanshinquinone	Structural Classification Natural Products Leguminosae Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	Parasite
Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .

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Trypanosoma brucei

Inhibitors & Agonists

NaturalProducts

Natural
Products